"Unlocking the Power of Coffee and the Body: Enhancing Muscle Function with a Natural Molecule for Aging"

In a groundbreaking discovery, researchers from Nestlé Research in Switzerland and the Yong Loo Lin School of Medicine at the National University of Singapore have unveiled an exciting breakthrough in the fight against muscle deterioration during aging. The key to this advancement lies in a natural molecule called trigonelline, which is not only found in coffee and fenugreek but also in the human body itself.

Sarcopenia, a condition characterized by the progressive weakening of muscles as we age, has long been a challenging hurdle in the quest for healthy aging. The research consortium, in collaboration with several esteemed universities worldwide, revealed that trigonelline levels are significantly lower in older individuals with sarcopenia. Through experimental models, they demonstrated that supplementing trigonelline led to a surge in NAD+ levels, enhanced mitochondrial activity, and ultimately preserved muscle function in the face of aging.

NAD+, a crucial cellular cofactor essential for energy production, typically decreases with age, contributing to muscle decline. By introducing trigonelline into the equation, researchers were able to boost NAD+ levels and reinvigorate mitochondrial function, offering a potential solution to combat the effects of sarcopenia.

The study, published in Nature Metabolism, sheds light on a new avenue for enhancing NAD+ levels through trigonelline, paving the way for future interventions aimed at promoting healthy aging and addressing age-related diseases. Assistant Professor Vincenzo Sorrentino expressed enthusiasm about the findings, underscoring the significance of trigonelline as a novel NAD+ precursor with wide-ranging implications for longevity and age-related ailments.

Moreover, the research underscores the importance of nutrition and physical activity in maintaining muscle health as we grow older. By highlighting the synergistic relationship between a natural compound found in food and key mechanisms of aging, the study opens up promising possibilities for translating these discoveries into real-world applications.

Jerome Feige from Nestlé Research emphasized the transformative potential of trigonelline in rejuvenating cellular metabolism and bolstering muscle vitality during the aging process. This innovative approach offers a ray of hope for individuals grappling with the challenges of sarcopenia and underscores the power of natural compounds in promoting healthy aging.

As the scientific community delves deeper into the complex interplay between trigonelline, NAD+, and muscle health, the future holds immense promise for developing targeted therapies and interventions that could revolutionize the way we approach aging and age-related conditions.

Source: https://www.eurekalert.org/news-releases/1038568