Creating gold nanoparticle arrays on a wafer scale improves biosensing capabilities.

In a groundbreaking study led by Prof. LI Yue from the Hefei Institutes of Physical Science (HFIPS) at the Chinese Academy of Sciences (CAS), a new self-confined solid-state dewetting mechanism has been introduced. This innovative approach revolutionizes the nanofabrication process by enabling efficient wafer-scale patterning of non-closely packed (ncp) gold nanoparticle arrays. The study, published in Advanced Science, addresses the limitations faced by gold nanostructures in biosensing applications, particularly due to ohmic and radiative losses in metal.

The strategic arrangement of gold nanostructures into 2D ncp arrays has been shown to reduce radiative loss, supporting a plasmonic surface lattice resonance (SLR) property that theoretically enhances sensitivity by two orders of magnitude. The research team uncovered the self-confined solid-state dewetting mechanism, which represents a paradigm shift in nanofabrication techniques for creating ncp gold nanoparticle arrays on a wafer scale. By combining this mechanism with a soft lithography process, they overcame reproducibility challenges associated with colloidal crystal self-assembly.

This novel method allows for the batch fabrication of ncp gold arrays with consistent ordering and optical properties. These nanoparticle arrays exhibit strong SLR properties that are conducive to sensing tiny molecules upon excitation by light. The development of sensitive plasmonic sensing of molecular interactions through a simple transmission setup holds significant promise for the creation of more efficient portable devices for detecting trace amounts of substances.

Dr. LIU Dilong, a key member of the research team, expressed optimism about the implications of this work, stating that it could lead to sensitive SLR biosensing applications and pave the way for commercializing portable biosensing devices. The study, titled "Self-Confined Dewetting Mechanism in Wafer-Scale Patterning of Gold Nanoparticle Arrays with Strong Surface Lattice Resonance for Plasmonic Sensing," was published on January 15, 2024, in Advanced Science.

Overall, this innovative research not only advances the field of biosensing but also offers a new avenue for the development of portable biosensing technologies with enhanced sensitivity and performance.

Source: https://www.eurekalert.org/news-releases/1036887

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